Catalysis#

class biopax-explorer.biopax.catalysis.Catalysis(*args, **kwargs)[source]#

Bases: Control

Class Catalysis

Definition: A control interaction in which a physical entity (a catalyst)

increases the rate of a conversion interaction by lowering its activation energy. Instances of this class describe a pairing between a catalyzing entity and a catalyzed conversion. Rationale: Catalysis, theoretically, is always bidirectional since it acts by lowering the activation energy. Physiologically, however, it can have a direction because of the concentration of the participants. For example, the oxidative decarboxylation catalyzed by Isocitrate dehydrogenase always happens in one direction under physiological conditions since the produced carbon dioxide is constantly removed from the system. Usage: A separate catalysis instance should be created for each different conversion that a physicalEntity may catalyze and for each different physicalEntity that may catalyze a conversion. For example, a bifunctional enzyme that catalyzes two different biochemical reactions would be linked to each of those biochemical reactions by two separate instances of the catalysis class. Also, catalysis reactions from multiple different organisms could be linked to the same generic biochemical reaction (a biochemical reaction is generic if it only includes small molecules). Generally, the enzyme catalyzing a conversion is known and the use of this class is obvious, however, in the cases where a catalyzed reaction is known to occur but the enzyme is not known, a catalysis instance can be created without a controller specified. Synonyms: facilitation, acceleration. Examples: The catalysis of a biochemical reaction by an enzyme, the enabling of a transport interaction by a membrane pore complex, and the facilitation of a complex assembly by a scaffold protein. Hexokinase -> (The “Glucose + ATP -> Glucose-6-phosphate +ADP” reaction). A plasma membrane Na+/K+ ATPase is an active transporter (antiport pump) using the energy of ATP to pump Na+ out of the cell and K+ in. Na+ from cytoplasm to extracellular space would be described in a transport instance. K+ from extracellular space to cytoplasm would be described in a transport instance. The ATPase pump would be stored in a catalysis instance controlling each of the above transport instances. A biochemical reaction that does not occur by itself under physiological conditions, but has been observed to occur in the presence of cell extract, likely via one or more unknown enzymes present in the extract, would be stored in the CONTROLLED property, with the CONTROLLER property empty.

code generator : rdfobj (author F.Moreews 2023-2024).

Methods

get_availability()

Attribute _availability getter

get_catalysisDirection()

Attribute _catalysisDirection getter

get_cofactor()

Attribute _cofactor getter

get_comment()

Attribute _comment getter

get_controlType()

Attribute _controlType getter

get_controlled()

Attribute _controlled getter

get_controller()

Attribute _controller getter

get_dataSource()

Attribute _dataSource getter

get_displayName()

Attribute _displayName getter

get_evidence()

Attribute _evidence getter

get_interactionType()

Attribute _interactionType getter

get_name()

Attribute _name getter

get_participant()

Attribute _participant getter

get_standardName()

Attribute _standardName getter

get_xref()

Attribute _xref getter

attribute_type_by_name

get_uri_string

object_attributes

set_availability

set_catalysisDirection

set_cofactor

set_comment

set_controlType

set_controlled

set_controller

set_dataSource

set_displayName

set_evidence

set_interactionType

set_name

set_participant

set_standardName

set_uri_string

set_xref

to_json

type_attributes

Methods Summary

attribute_type_by_name()

get_catalysisDirection()

Attribute _catalysisDirection getter

get_cofactor()

Attribute _cofactor getter

get_uri_string()

object_attributes()

set_catalysisDirection(value)

set_cofactor(value)

set_uri_string(uristr)

to_json()

type_attributes()

Methods Documentation

attribute_type_by_name()[source]#
get_catalysisDirection()[source]#
Attribute _catalysisDirection getter

This property represents the direction of this catalysis under all physiological

conditions if there is one. Note that chemically a catalyst will increase the rate of the reaction in both directions. In biology, however, there are cases where the enzyme is expressed only when the controlled bidirectional conversion is on one side of the chemical equilibrium. For example E.Coli’s lac operon ensures that lacZ gene is only synthesized when there is enough lactose in the medium. If that is the case and the controller, under biological conditions, is always catalyzing the conversion in one direction then this fact can be captured using this property. If the enzyme is active for both directions, or the conversion is not bidirectional, this property should be left empty.

get_cofactor()[source]#
Attribute _cofactor getter

Any cofactor(s) or coenzyme(s) required for catalysis of the conversion by the

enzyme. This is a suproperty of participants.

get_uri_string()[source]#
object_attributes()[source]#
set_catalysisDirection(value)[source]#
set_cofactor(value)[source]#
set_uri_string(uristr)[source]#
to_json()[source]#
type_attributes()[source]#